Current Issue : January-March Volume : 2013 Issue Number : 1 Articles : 6 Articles
Gastric cancer represents a challenging health problem around the world and is one of the top causes of cancer-related deaths. Challenges in treatment of advanced gastric cancer are due to the relative resistance of disease to treatment, the frequent occurrence of symptomatic disease or impaired performance status of patients, and the propensity of gastric cancer to present when it has become locally advanced or metastatic. Recently, remarkable progress in tumor biology has led to the development of new agents that target critical aspects of oncogenic pathways. This review provides an updated summary of the current status of gastric cancer diagnosis, management, cytotoxic chemotherapy, emphasize on many chemotherapeutic options available and the reasoning that clinicians use in choosing the right treatment option for the right patient. As per the current clinical trial studies the combination therapy shows promising success rate, Pac-5-FU(56%), Cape-Cis(55%), DCF(54%), UFT-Cis(51%), CPT-Cis(50%), 5-FU-Oxal(48%), FOLFOX-4(45%). The advances in individualization of therapy offer a treatment care plan with a high rate of success and minimal toxicity. Recent progress in treatment of gastric cancer includes biologically targeted therapies (a recombinant humanized monoclonal antibody to vascular endothelial growth factor), Monoclonal Antibodies and tyrosine kinase Inhibitors, predictive markers of response, surrogate markers of response, use of nanotechnology whose scope will only increase as the understanding of the pathophysiology and carcinogenesis of this disease improves....
GERD(gastro esophageal reflux disorder) is a mucosal damage caused by stomach acid coming up from the stomach into the esophagus i.e. acid reflux (gastro esophageal reflux) which is a backflow of stomach contents upward into the esophagus.In view of the shortcomings in the existing methods for the treatment of GERD,it has been the aim of the researchers to try and come up with newer methods,with an aim to better the treatment regime. This review focuses on the recent advances in the treatment of GERD, including novel instrumentation as well as newer drugs....
Emus belong to ratite group and have high economic value for their meat, eggs, oil, skin and feathers. Ratite birds have poorly developed wings and include emu, ostrich, rhea, cassowary and kiwi. Emu a large flightless hardy bird of Australian origin can survive in temperatures ranging from two degrees to fifty degrees Celsius. These birds can be well maintained on extensive (ranches) and semi intensive rearing systems with reasonably high fibrous diets. United State, Australia and China are leading in emu farming. Emu birds are well adapted to Indian climatic conditions. Although emu farming is considered to be high economical, we have to study the ethology of emus to increase the profitability by providing housing, feeding and breeding facilities more or less similar to that of in wild condition during their rearing in captivity and we will have to carry out comparative study of behaviour in captivity as well as in wild condition....
Parkinson’s disease (PD) is a neurodegenerative disorder affecting the physical, psychological, social, and functional status of individuals. Exercise programs may be an effective strategy to delay or reverse functional decline for people with PD and a large body of empirical evidence has emerged in recent years. Evidence supported proper information about Parkinson’s disease and its remedies. The goal of this project is to identify key molecular events involved at early stages in PD and exploit these as potential points of therapeutic intervention. Age is the most consistent risk factor for PD, and as we have an aging population, it is of upmost importance that we find therapies to limit the social, economic and emotional burden of this disease. Most of the studies to find better drugs for PD have been done in rodents. However, many of these drugs failed when tested in PD patients. One problem is that we can only investigate the diseased neurons of the brain after the PD patients have died....
Liver disease complication is one of the most common causes of morbidity and mortality in diabetic patients. Hepatotoxicity did not receive as much attention as other prevalent complications (i.e., Cardiopathy, Retinopathy and Nephropathy) until hepatotoxicity of antidiabetic drugs emerged as a common clinical complication. This article is an attempt to summarize the current understanding of hepatotoxicity of antidiabetic drugs. Diabetic mice appear to be less susceptible to show hepatotoxicity at same doses compared to rats, suggest that for study as hepatotoxicity mice may not be a preferred species to study long term toxicity specifically related to liver function in diabetic condition....
Xenotransplantation like is transplantation is just like a dream comes true. Several barriers & issues are there as in case of xerograph & xenotransplantation, like selection of animal, after transplantation organ rejection, immunosupressives regiment. Issues due to immunosupression, overcoming therapy, recent reserch.overall if organ of selected animal is succesfullily transplanted to human the we save lots of lives having problems of organ failure....
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